Tetsuo Yukioka Author
Subjects of specialization
Affiliation
Emergency Medicine, Critical Care Medicine
Department of Emergency and Critical Care Medicine, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan.
He is affiliated to Department of Emergency and Critical Care Medicine, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan. His international experience includes various programs, contributions and participation in different countries for diverse fields of study.
Research Article Subscription
Author(s): Takao Arai, Shiro Mishima, Shoichi Ohta, Tetsuo Yukioka and Tetsuya Matsumoto
Objective: Probiotics exert beneficial effects on gastrointestinal microflora, but these effects may be counteracted by antibiotics, particularly when used in critically ill patients. The aim of this study was to examine the effects of probiotics in association with antibiotics on septicemia markers.
Methods: In total, 64 critically ill patients were randomized to receive conventional therapy alone (control group) or with a transluminal preparation containing Bifidobacterium longum BB536 (probiotic group). Patients were retrospectively divided into two subgroups depending on whether they received antibiotic therapy during the study period. Outcome measures included fecal bifidobacteria numbers and serum concentrations of procalcitonin and interleukin 6.
Results: Af... view moreĀ»