Varriano B Author
Subjects of specialization
Affiliation
dementia , Neurodegenerative disorders
Maple Leaf Medical Clinic, Canada Institute of Medical Science, University of Toronto, Canada
Brenda Varriano obtained her MSc. with the Institute of Medical Sciences at the University of Toronto. She has completed her BSc. in Psychology, Physiology and Human Biology at the University of Toronto, St. George. She has finished as a Deans Scholar and recipient of the Silver Medal for academic achievement. Her interests include sports medicine and neurodegenerative disorders, especially post concussion syndrome, dementia
Research Article Open Access
Author(s): Steinberg S, Loutfy M, Sandler I, Varriano B, Smith G, Kovacs C, Brunetta J, Chang B, Merkley B, Tilley D, Fletcher D, Acsai M, Knox D and Crouzat F
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are prone to baseline resistance and potential early treatment failure. We investigated the NNRTI resistance profiles of antiretroviral therapy (ART)–naive patients with HIV in a large urban clinic and assessed their response to initial ART.
Materials and Methods: This was a retrospective cohort study of ART-naive patients, who had baseline genotypes, starting ART prior to July 16, 2015. Cox regression was used to determine the impact on time to viral suppression with baseline NNRTI resistance as the primary covariate of interest. Of those who achieved virologic suppression, Cox regression was used to determine the impact on viral rebound [viral load (VL) ≥ 200 copies/... view more»