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Hindi Journal of Nephrology & Renal DiseasesISSN: 2576-3962
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Voinov V.A. Author
Subjects of specialization
Affiliation
Nephrology
First Saint Petersburg State Medical University, Saint Petersburg, Russia
Biography
Diabetic nephropathy is a serious complication of diabetes up to development of terminal renal failure with a high mortality rate. It is important to realize that in its pathogenesis there is accumulation of various pro-inflammatory cytokines, chemokines, adhesion molecules, uric acid and glycated hemoglobin, as well as oxidative stress with increased activity of the renin-angiotensin-aldosterone system. In this case there is thickening of the glomerular basement membrane, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis
Publications
Research Article Open Access
Plasmapheresis in diabetic nephropathy prevention and treatment
Author(s): Voinov V.A. and Voinova Ya.V
Diabetic nephropathy is a serious complication of diabetes up to development of terminal renal failure with a high mortality rate. It is important to realize that in its pathogenesis there is accumulation of various pro-inflammatory cytokines, chemokines, adhesion molecules, uric acid and glycated hemoglobin, as well as oxidative stress with increased activity of the renin-angiotensin-aldosterone system. In this case there is thickening of the glomerular basement membrane, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis. Treatment is mainly based on the control of sugar levels and blood pressure and there is practically no validated therapy that can stop the kidney damage progression. Therefore, in all these cases, plasmapheresis is almost the only and... view more»
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