Xianwei Zhang Author

Research Article Open Access

Analgesic Efficacy and Safety of Butorphanol versus Morphine in Adults: A Meta-Analysis of Randomized Controlled Trials

Author(s):

Changmao Zhu, Cong Wang, Jiaoli Sun, Ningbo Li, Yi Liu, Jin Zhang and Xianwei Zhang

Background: Morphine, a reference analgesic, has been widely used for a long time, but its safety profile is unsatisfactory. Butorphanol, a partial agonist and antagonist of the mu-opioid receptor and agonist of the kappa-opioid receptor, may offer a better safety profile than morphine. Therefore, the present meta-analysis was conducted to compare the analgesic efficacy and safety of butorphanol with that of morphine.

Methods: Three electronic databases, MEDLINE, EMBASE, and Cochrane CENTRAL, were systematically searched to identify studies comparing the analgesic efficacy and safety of butorphanol with that of morphine. If heterogeneity tests revealed statistical heterogeneity, pooled analysis was conducted using a random-effects model; otherwi... view more»

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