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Hindi Journal of Regenerative MedicineISSN: 2325-9620
Yiqiang Zhang Author
Subjects of specialization
Affiliation
Cell Culture, Gene Function Analysis
Department of Medicine/ Cardiology, University of Washington, USA
Biography
Yiqiang Zhang is an biomedical researcher focusing on finding molecular mechanisms underlying aging process and the development of age-associated diseases, in an effort to translate basic research to clinical applications translational research research. I have been well trained in molecular, cellular, biochemical, and microbial biology. Have extensive experience in animal models (transgenic and knockout rodent models), cell culture, gene function analysis/cloning, and imaging (FRET, confocal). In addition, I have strong background in microbiology. My focus has been on the molecular signaling pathways in response to stresses, such as oxidative stress and DNA damage.
Publications
Research Article Subscription
Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry
Author(s): Yiqiang Zhang, Noriko Matsushita, Tamar Eigler and Eduardo Marban
Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry
Mammalian heart cells undergo a marked reduction in proliferative activity shortly after birth, and thereafter grow predominantly by hypertrophy. Our understanding of the molecular mechanisms underlying cardiac maturation and senescence is based largely on studies at the whole-heart level. Here, we investigate the molecular basis of the acquired quiescence of purified neonatal and adult cardiomyocytes, and use microRNA interference as a novel strategy to promote cardiomyocyte cell cycle re-entry. Expression of cyclins and cyclin-dependent kinases (CDKs) and positive ... view more»
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