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Hindi Analgesia & Resuscitation : Current ResearchISSN: 2324-903X
Yun Guan Author
Subjects of specialization
Affiliation
Neurobiology, Pain Perception, Neurobiology, Pain Medicine, Neuropharmacology
Division of Pain Medicine, Department of Anesthesiology/CCM, the Johns Hopkins University, 720 Rutland Ave., Ross 351, Baltimore, MD 21205, USA
Biography
Dr. Yun Guan is an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His multidisciplinary research focuses on mechanisms of chronic pain and developing better strategies and novel targets for treatment of pathological pain conditions. His team is currently engaged in research that studies the neurobiological mechanisms of pain and hyperalgesia after tissue or nerve injury.
Publications
Editorial Open Access
An Emerging Role of MrgC in Inhibiting Neuropathic Pain
Author(s): Yun Guan
An Emerging Role of MrgC in Inhibiting Neuropathic Pain
The treatment of nonmalignant neuropathic pain continues to challenge clinicians owing to the limited efficacy of available treatments, dose-limiting adverse effects of drugs that are available, and lack of pain-specific treatment targets. G protein-coupled receptors (GPCRs) have been used frequently as drug targets for a variety of pharmacotherapies, including those for pathological pain. One novel family of GPCRs, the so-called Mas-related G protein-coupled receptors (Mrgs) may play a role in the function of nociceptive neurons as well as in sensation and modulation of pain.
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