Zhen Zong Lim Author

Annual Meeting Abstract Open Access

Euro Infectious Diseases 2020: Exploring potential therapeutics targeting coronavirus spike glycoproteins and how they might be utilized for treatment of SARS-CoV-2 - Zhen Zong Lim - Imperial College

Author(s):

Zhen Zong Lim

The recent irruption of the novel SARS-CoV-2 has resulted in an exceedingly worldwide pandemic and left health care systems scrambling to address the sheer magnitude of the malady irruption. taxonomical analysis of respiratory disorderCoV-2 showed it to be a successor of SARS-CoV that caused the 2003 SARS pandemic. SARS-CoV-2 microorganism entry into host cells is analogous to connected coronaviruses SARSCoV and HCoV-NL63, with all 3 viruses utilizing Spike (S) conjugated protein to act with ACE2 receptor. SARS-CoV-2 and SARS-CoV S conjugated protein conjointly shares 77-80% primary amino alkanoic acid sequence identity. Many medicines are developed and shown to be effective against SARS-CoV and HCOV-NL63 microorganism entry. As such, we tend to investigate the medicine targeting SARS-C... view more»

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