International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 4 Issue: 5

Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension [Retrieved]

Zeenat Safdar1*, Aishwarya Thakur1, Supriya Singh1, Yingqun Ji1, Danielle Guffey2, Charles G Minard2 and Mark L Entman3
1Division of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Texas, USA
2Dan L Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, USA
3Division of Cardiology, Baylor College of Medicine, Texas, USA
Corresponding author : Zeenat Safdar, MD
Associate Professor of Medicine, Director, Baylor Pulmonary Hypertension Program, Pulmonary-Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Tel: +713 798 2400; Fax: 713 798 2688
E-mail: [email protected]
Received: April 01, 2015 Accepted: May 19, 2015 Published: May 21, 2015
Citation: Safdar Z, Thakur A, Singh S, Ji Y, Guffey D, et al. (2015) Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension. Int J Cardiovasc Res 4:5. doi:10.4172/2324-8602.1000227

Abstract

Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension

Objective: It is not known whether aldosterone levels are associated with increased mortality in patients with pulmonary arterial hypertension (PAH). The goal of this study was to determine whether circulating aldosterone levels can predict the severity of (PAH) in terms of hemodynamic characteristics and mortality.

Methods: Patients with stable PAH were prospectively enrolled at the Baylor PH program. The plasma levels of aldosterone and BNP were measured. Clinical, hemodynamic, and outcome data was collected. Mean follow up time from study enrollment to follow up was 39 ± 102 months. Cox proportional hazards model was used to assess time to death.

Keywords: Pulmonary arterial hypertension; Aldosterone; Right ventricle; Mineralocorticoid receptor antagonist

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