Reach Us +1 850 900 2634

International Journal of Cardiovascular ResearchISSN: 2324-8602

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, Int J Cardiovasc Res Vol: 4 Issue: 2

Collagen Metabolism Biomarkers and Health Related Quality of Life in Pulmonary Arterial Hypertension

Zeenat Safdar1*, Emilio Tamez1, Adaani Frost1, Danielle Guffey2, Charles G Minard2 and Mark L Entman3
1Division of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, USA
2Dan L Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, USA
3Division of Cardiology, Baylor College of Medicine, USA
Corresponding author : Zeenat Safdar, MD
FACP, Associate Professor of Medicine, Baylor Pulmonary Hypertension Program, Baylor College of Medicine, Houston, Texas 77030, USA
Tel: + 713 798 2400; Fax: 713 798 2688
E-mail: [email protected]
Received: September 18, 2014 Accepted: January 23, 2015 Published: January 25, 2015
Citation: Safdar Z, Tamez E, Frost A, Guffey D, Minard CG, et al. (2015) Collagen Metabolism Biomarkers and Health Related Quality of Life in Pulmonary Arterial Hypertension. Int J Cardiovasc Res 4:2. doi:10.4172/2324-8602.1000198

Abstract

 Collagen Metabolism Biomarkers and Health Related Quality of Life in Pulmonary Arterial Hypertension

Objectives: The goal of this study was to investigate the association between collagen metabolism biomarkers and health related quality of life (HRQoL) in PAH patients. Methods: We prospectively enrolled 68 stable idiopathic, anorexigen-associated, and hereditary PAH subjects and 37 healthy controls. Serum samples were analyzed for N-terminal propeptide of type III procollagen (PIIINP), c-terminal telopeptide of collagen type I (CITP), matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1). The Minnesota Living with Heart Failure (MLWHF), EQ-5D (EQ-5D), Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and Short Form (SF-36) general health survey were administered at the time of blood draw. General linear models, as well as logistic regression models were used to assess associations between variables. Results: CITP, PIIINP, MMP9, and TIMP1 levels, and all HRQoL domains were significantly different between controls and PAH patients (p<0.001 for each). Interestingly, PIIINP levels were significantly associated with MLWHF physical (coef=1.63, and p=0.02), SF-36 physical (coef=-2.93, p=0.004), and EQ-5D aggregate (coef=0.34, p=0.001) scores. Several of the CAMPHOR scores strongly linearly associated with PIIINP. The odds of obtaining a walk distance ≥330 meters decrease by 38% per unit increase in PIIINP (OR=0.62; 95% CI=0.43, 0.90) and a PIIINP cutoff of 5.53 μg/L provided 81% sensitivity and 82% specificity. Conclusions: PIIINP is the best predictor of disease severity, and is strongly related to HRQoL scores in PAH patients. These relationships suggest PIIINP as a promising tool for PAH clinicians to determine or confirm the level of disease severity.

Keywords:

Track Your Manuscript

Share This Page

Media Partners