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International Journal of Cardiovascular ResearchISSN: 2324-8602

Review Article, Int J Cardiovasc Res Vol: 2 Issue: 5

Developmental Origins of Cardiovascular Disease. A Missing Link in the Puzzle

Maqsood M Elahi1 and Bashir M Matata2*
1Division of Cardiothoracic Surgery, Department of Surgery, Texas A and M Health Science Centre at Scott and White Memorial Hospital, Texas, USA
2Department of Clinical Research, The Liverpool Heart and Chest Hospital NHS Foundation Trust, Thomas Drive, Liverpool, L14 3PE, United Kingdom
Corresponding author : Matata BM
Liverpool Heart and Chest Hospital NHS Foundation Trust, Thomas Drive, Liverpool, L14 3PE, UK
Tel: +44-151-600-1380
E-mail: [email protected]
Received: July 03, 2013 Accepted: August 29, 2013 Published: September 06, 2013
Citation: Elahi MM, Matata BM (2013) Developmental Origins of Cardiovascular Disease. A Missing Link in the Puzzle. Int J Cardiovasc Res 2:5. doi:10.4172/2324-8602.1000140

 

Abstract

Developmental Origins of Cardiovascular Disease. A Missing Link in the Puzzle

Cardiovascular disease (CVD) is the leading cause of death worldwide and cause of early death in developing countries. The acceleration of early CVD epidemic is believed to be a consequence of interaction between the distribution of relative genotype frequencies and environmental exposures. In accordance with the developmental origin of health and disease (DOHaD)hypothesis adverse intrauterine influences such as poor maternal nutrition lead to impaired fetal growth. These adverse influences are postulated to also induce the fetus to develop adaptive metabolic and physiological responses.

Keywords: Cardiovascular disease, genetic variations, developmental origin of health and disease, DNA variations

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