Reach Us +1 850 900 2634

International Journal of Cardiovascular ResearchISSN: 2324-8602

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, Int J Cardiovasc Res Vol: 4 Issue: 1

Effect of Primary Percutaneous Coronary Intervention on Renal Function in Acute ST Elevation Myocardial Infarction

Georgios C Lygouris1, Vinay Mehta1, Shuchita Gupta1, D Lynn Morris1,2 and Vincent M Figueredo1,2*
1Einstein Medical Center, Philadelphia, USA
2Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, USA
Corresponding author : Vincent M. Figueredo, MD
Einstein Heart and Vascular Institute, 5501 Old York Road, 19141, Philadelphia, USA
Tel: 215-456-8819; Fax: 215-456-3533
E-mail: [email protected]
Received: November 21, 2014 Accepted: December24, 2014 Published: January 01, 2015
Citation: Lygouris CG, Mehta V, Gupta S, Morris LD, Figueredo VM, et al. (2015) Effect of Primary Percutaneous Coronary Intervention on Renal Function in Acute ST Elevation Myocardial Infarction. Int J Cardiovasc Res 4:1. doi:10.4172/2324-8602.1000193

Abstract

 Effect of Primary Percutaneous Coronary Intervention on Renal Function in Acute ST Elevation Myocardial Infarction

Objectives: Assess the effect of primary percutaneous coronary intervention (PCI) on renal function in the setting of acute ST elevation myocardial infarction (STEMI). Methods: Retrospective chart review of 270 STEMI patients that underwent primary PCI. Creatinine clearance was calculated using the re-expressed 4–variable Modification of Diet in Renal Disease (MDRD) formulas upon presentation to emergency room and prior to discharge from hospital or death. Results: Mean creatinine level upon presentation was 1.14 ± 0.43 mg/dl and upon discharge 1.07 ± 0.51 mg/dl (p=0.013). Mean CrCl on admission was 77 ± 27 ml/min/1.73m2 and improved to 86 ± 31 ml/min/1.73m2 upon discharge (p<0.001). This improvement was observed in patients with all stages of chronic kidney disease (CKD), including stage III (47 ± 9 vs 55 ± 18 ml/min/1.73m2, p=0.001) and stage IV (24 ± 4 vs 29 ± 10 ml/min/1.73m2; p=0.13). Statistically significant improvement in CrCl (79 ± 28 vs. 86 ± 31 ml/min/1.73m2, p < 0.001) was observed in African American patients (72% of study group). Conclusion: In STEMI patients, primary PCI does not appear to be associated with worsening, but rather an improvement, in renal function upon hospital discharge.

Keywords: Creatinine clearance, percutaneous coronary intervention, ST elevation myocardial infarction

Track Your Manuscript

Share This Page

Media Partners