Andrology & Gynecology: Current ResearchISSN: 2327-4360

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Research Article, Androl Gynecol Curr Res Vol: 3 Issue: 2

Effects of SNPs in Nuclear factor kappa-B1, Poly (ADPribose) Polymerase-1 Genes on E-cadherin and Fibronectin Levels in Case of Male Infertility

Pinar Elcin1, R Burak Tek2, Arzuhan Koc1*, Hulya Arkan1, Hamdi Ozkara2 and Gonul Kanigur-Sultuybek1
1Cerrahpasa Medical Faculty, Department of Medical Biology and Genetics, Istanbul University, Istanbul, Turkey
2Cerrahpasa Medical Faculty, Department of Urology, Istanbul University, Istanbul, Turkey
Corresponding author : Arzuhan Koc
Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, PO Box 34098, Istanbul, Turkey
Tel: 902124143034; Fax: +902124143032; E-mail: [email protected]
Received: July 14, 2015 Accepted: July 28, 2015 Published: August 04, 2015
Citation: Elcin P, Tek BR, Koc A, Arkan H, Ozkara H, et al. (2015) Effects of SNPs in Nuclear factor kappa-B1, Poly (ADP-ribose) Polymerase-1 Genes on E-cadherin and Fibronectin Levels in Case of Male Infertility. Androl Gynecol: Curr Res 3:2. doi:10.4172/2327-4360.1000137

Abstract

Effects of SNPs in Nuclear factor kappa-B1, Poly (ADPribose) Polymerase-1 Genes on E-cadherin and Fibronectin Levels in Case of Male Infertility

Infertile people include approximately 15% of couples all over the world. Male factor is responsible in 45-50% of cases. In approximately 50% of cases based on male problem are attributed to the abnormal spermatogenesis which result in oligospermia and asthenospermia. Many genes are involved in different stages of spermatogenesis, testicular differentiation and proliferation/apoptosis of germ cells. Rapid DNA changes in genes related to these processes have been shown to cause infertility.

Keywords: Single nucleotide polymorphism; Nuclear factor kappa-B1; Male infertility; E-cadherin; Fibronectin

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