International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 4 Issue: 3

Increased pro-Oxidant- Antioxidant Balance in Patients with Diabetes Mellitus

Seyed Reza Mirhafez1,2*#, Amir Avan2#, Raheleh Darsouie2,3#, Alireza Heidari-Bakavoli4, Seyed Mohammad Reza Parizadeh5, Mohsen Mazidi5, Hossein Savadi6, Mahmoud Ebrahimi4, Gordon A Ferns7 and Majid Ghayour-Mobarhan2,5*
1Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
2Department of Modern Sciences and Technologies, Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Biochemistry, Payam Noor University of Mashhad, Mashhad,Iran
4Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran
7Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK
Corresponding author : Majid Ghayour-Mobarhan, MD, PhD
Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Tel: +985118002288; Fax: +985118002287
E-mail: [email protected]
Received: December 11, 2014 Accepted: March 04, 2015 Published: March 06, 2015
Citation: Mirhafez SR, Avan A, Darsouie R, Heidari-Bakavoli A, Parizadeh SMR, et al. (2015) Increased pro-Oxidant–Antioxidant Balance in Patients with Diabetes Mellitus. Int J Cardiovasc Res 4:3. doi:10.4172/2324-8602.1000207

Abstract

 Increased pro-Oxidant– Antioxidant Balance in Patients with Diabetes Mellitus

Background: Diabetes mellitus (DM) is a common metabolic condition affecting populations globally. Diabetes mellitus is associated with an imbalance between pro-oxidant mechanisms and the antioxidant defenses, contributing to oxidative-stress, and this is associated with an increased susceptibility to endothelial dysfunction, atherosclerosis, insulin-resistance and impairedpancreatic β-cell function. Here we have investigated the serum pro-oxidant/antioxidant balance (PAB) in the patients with diabetes and healthy subjects. Methods: Serum PAB was assessed in 658 subjects, comprised of 69 patients with diabetes, 81 subjects with impaired fasting glucose (IFG) and 508 healthy-subjects. Results: The diabetic patients had significantly higher fasting blood glucose (FBG) and serum triglycerides (TG), compared to subjects with IGT IFG and healthy individuals. Median serum PAB values were significantly higher in the patients with diabetes (92.03 [interquartile-range [IQ]: 31.40-124.56]) compared to the healthy group (48.1 [IQ: 20.6-85.9]; P<0.05). Multivariate-linear-regression model and binary-regression-logistic analysis showed that PAB, FBG and TG were significantly associated with DM. Conclusion: In diabetics there is an imbalance between serum pro-oxidant and antioxidant activity. Furthermore, our findings indicate that this assay could be used along with other risk factors to estimate the oxidative stress in high-risk patients.

Keywords: Diabetes; Prooxidant-antioxidant balance; Oxidative stress

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