International Journal of Cardiovascular ResearchISSN: 2324-8602

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Review Article, Int J Cardiovasc Res Vol: 1 Issue: 3

Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells

Fatemeh Pourrajab1,2*, Seyed Khalil Forouzannia1, Seyed Hossain Hekmatimoghadam1,3 and Marjan Tajik kord2
1Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Clinical Biochemistry and Molecular Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3School of paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Corresponding author : Fatemeh Pourrajab, Ph.D
Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Gomhoori BLV, Yazd, Iran, Postal Code: 8917945556
Tel: +983515231421; Fax: +983515253335
E-mail: [email protected]
Received: July 01, 2012 Accepted: July 28, 2012 Published: August 06, 2012
Citation: Pourrajab F, Forouzannia SK, Hekmatimoghadam SH, Kord MT (2012) Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells. Int J Cardiovasc Res 1:3. doi:10.4172/2324-8602.1000102

Abstract

Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells

For successful systemic stem cell therapy, BMSCs must transmigrate across the endothelium and invade their target tissue.A prerequisite for a successful usage of BMSCs is that they exit the blood circulation via transmigration and invasion. The endothelial phenotype selectively modulates BMSCs transmigration and morphological changes. BMSCs exit the blood circulation by integrating into the endothelium, penetrating the basement membrane and invading the surrounding tissue via the formation of plasmic podia.

Keywords: Vascular phenotype; Key mechanism;Transmigration; Homing; Molecular mechanism

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