Journal of Immunodeficiency & DisordersISSN: 2324-853X

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Research Article, J Immunodefic Disor Vol: 2 Issue: 1

Non-Antibacterial Implications of Tetracyclines in the Management of Periodontitis: An Update

Bangalore Varadhan Karthikeyan*, Devireddy Venkata Tejaswi and Munivenkatappa Lakshmaiah Venkatesh Prabhuji
Department of Periodontics, Krishnadevaraya College of Dental Sciences, Bangalore, India
Corresponding author : Bangalore Varadhan Karthikeyan
Department of Periodontics, Krishnadevaraya College of Dental Sciences, Hunasamaranahalli, via Yelahanka, Bangalore- 562157, India
E-mail: drkarthikeyanbv@rediffmail.com
Received: May 20, 2013 Accepted: July 08, 2013 Published: July 15, 2012
Citation: Karthikeyan BV, Tejaswi DV, Prabhuji MLV (2012) Non-Antibacterial Implications of Tetracyclines in the Management of Periodontitis: An Update. J Immunodefic Disor 2:1. doi:10.4172/2324-853X.1000104

Abstract

Non-Antibacterial Implications of Tetracyclines in the Management of Periodontitis: An Update

Recent research has shown that the majority of the soft and hard tissue destruction in periodontitis occurs due to activated host immuneinflammatory defence mechanisms in response to bacterial plaque. The importance of the host inflammatory response in periodontal pathogenesis presents opportunity for exploring new treatment strategies for periodontitis by means of host modulation. One of such treatment strategy is the use of drugs like Chemically Modified Tetracyclines, which are derivatives of tetracycline group of antibiotics, but lack antimicrobial action and have potent host modulating properties. The main advantage of Chemically Modified Tetracyclines over conventional tetracyclines is that they do not produce the side effects such as gastro-intestinal toxicity and antibiotic resistance.

 

Keywords: Periodontitis; Host modulation; Chemically modified tetracyclines; Antibiotic resistance

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