Journal of Marine Biology & Oceanography ISSN: 2324-8661

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Research Article, J Mar Biol Oceanogr Vol: 3 Issue: 4

Antileishmanial Potential of Chondrococcus hornemanni against Experimental Visceral Leishmaniasis

Vijai Lakshmi1*, Prashant Khare2, Pragya Misra2, Srivastava MN3 and Anuradha Dube2
1Divisions of Medicinal & Process Chemistry, CSIR- Central Drug Research Institute, Lucknow, India
1Division of Parasitology, CSIR- Central Drug Research Institute, Lucknow, India
3Division of Botany, CSIR- Central Drug Research Institute, Lucknow, India
Corresponding author : Vijai Lakshmi
Department of Biochemistry, King George’s Medical University, Lucknow, India
Tel: +91-(0522)–2254604
E-mail:
[email protected]
Received: April 17, 2014 Accepted: August 30, 2014 Published: September 05, 2014
Citation: Lakshmi V, Khare P, Misra P, Srivastava MN, Dube A (2014) Antileishmanial Potential of Chondrococcus hornemanni against Experimental Visceral Leishmaniasis. J Mar Biol Oceanogr 3:4. doi:10.4172/2324-8661.1000137

Abstract

 Antileishmanial Potential of Chondrococcus hornemanni against Experimental Visceral Leishmaniasis

Exploration of safe and effective antileishmanials from natural resources is an active area of research. Therefore we have selected C. hornemanni to evaluate its antileishmanial potential. The crude ethanol extract and its fractions were tested both in vitro and in vivo. The crude ethanol extract yielded almost (88.0 ± 6.9% inhibition of promastigotes and 75.8 ± 5.2% inhibition of intracellular amastigotes at 100 μg/ml concentration with IC50 values of 29.5 μg/ml and 40.6 μg/ml, respectively.

Keywords: Leishmania donovani; C. hornemanni; Antileishmanial activity

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