International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 7 Issue: 3

Comparison between GRACE and TIMI Risk Scores in Predicting the Severity and Extent of Coronary Artery Disease in Patients with NSTEACS

Reda B Bastawesy1, Hamza M Kabil1, Ahmed M Ramzy1, Mohamed M.Ali1 and Mostafa A. Elshahat2*

1Department of Cardiology, Benha Faculty of Medicine, Benha University, Benha, Egypt

2National Heart Institute, Cairo, Egypt

*Corresponding Author : Mostafa A Elshahat
National Heart Institute, Cairo, Egypt
Tel: 0233052972

Received: July 19, 2018 Accepted: July 25, 2018 Published: July 30, 2018

Citation: Bastawesy RB, Kabil HM, Ramzy AM, Ali MM, Elshahat MA (2018) Comparison between GRACE and TIMI Risk Scores in Predicting the Severity and Extent of Coronary Artery Disease in Patients with NSTE-ACS. Int J Cardiovasc Res 7:3. doi: 10.4172/2324-8602.1000352


Background: The prognostic value of the Global Registry of Acute Coronary Events (GRACE) risk score (GRS) and the thrombolysis in myocardial infarction (TIMI) risk index (TRI) has been reported in coronary artery disease (CAD) patients. We aimed to evaluate the relationship between the GRS, TRI, and severity of CAD evaluated by SYNTAX score (SS) in patients Non ST segment elvation acute coronary syndrome (NSTE-ACS).

Aim: The aim of this study is to compare the GRACE risk score and the TIMI risk index in predicting the extent and severity of coronary artery disease in patients with (NSTE-ACS) using Syntax score

Methods: A total number of 100 patients were admitted to National Heart Institute CCU with NSTE-ACS undergoing coronary angiography. Patients with a history of coronary artery bypass surgery, those who had missing data for calculating the GRS and TRI, and those whose systolic blood pressure (SBP) was more than 180 mm Hg or whose diastolic blood pressure (DBP) was more than 110 mm Hg were excluded from the study The GRS and TRI were calculated on admission using specified variables. The severity of CAD was evaluated using the SS. The patients were divided into low (GRS<109), intermediate (GRS 109-140), and high (GRS>140) risk groups according to GRS score and into group 1 (TRI 0-2), group 2 (TRI 3-4), and group 3 (TRI 5-7) according to TRI score. A Pearson correlation analysis was used for the relation between GRS, TRI, and SS.

Results: There were significant correlation between both GRACE and TRI score and SS (r=0.551, p<0.001) (r=0.309, p=0.046) respectively, there were no significant difference between area under the curve in predicting extent of CAD p= 0.185 although GRACE score showed higher significance in correlation with SS

 Conclusion: The GRS is more associated with SS than TRI in predicting the severity of CAD in patients with ACS

Keywords: Acute coronary syndrome; GRACE risk score; SYNTAX score; TIMI risk index

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