VEGETOS: An International Journal of Plant ResearchOnline ISSN: 2229-4473
Print ISSN: 0970-4078

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Research Article, Vegetos Vol: 30 Issue: 3

Comparison of the Phenolic Profile, Inhibition of Enzymes Associated with Type-2 Diabetes and Hypertension, and Fe2+- Induced Lipid Peroxidation in Rat’ Pancreas by Plum and Hogweed Leaves Extracts

Stephen Adeniyi Adefegha1, Sunday Idowu Oyeleye1,2*, Felix Abayomi Dada3, Opeyemi Babatunde Ogunsuyi1,2, Ganiyu Oboh1 and Aline Augusti Boligon4

1Department of Biochemistry, Federal University of Technology, Nigeria

2Department of Biomedical Technology, Federal University of Technology, Nigeria

3Department of Science Laboratory, Federal Polytechnic Ede, Nigeria

4Department of Chemistry, Federal University of Santa Maria, Brazil

*Corresponding Author : Sunday Idowu Oyeleye
Department of Biomedical Technology, Federal University of Technology, Akure, P.M.B. 704, Akure 340001, Nigeria
Tel: +234(0)8035123539
E-mail:
[email protected], [email protected]

Received: April 10, 2017 Accepted: April 25, 2017 Published: April 28, 2017

Citation: Adefegha SA, Oyeleye SI, Dada FA, Ogunsuyi OB, Oboh G, et al. (2017) Comparison of the Phenolic Profile, Inhibition of Enzymes Associated with Type-2 Diabetes and Hypertension, and Fe2+-Induced Lipid Peroxidation in Rat’ Pancreas by Plum and Hogweed Leaves Extracts. Vegetos 30:3. doi: 10.5958/2229-4473.2017.00158.6

Abstract

Inhibition α-amylase, α-glucosidase and angiotensin-I converting enzyme (ACE) are therapeutic approach to the management of type-2 diabetes (TD2) and hypertension, and phenolic-rich plants have shown promising potentials. Plum and Hogweed leaves are widely used across the world in managing TD2 without vivid scientific basis. This study investigated and compared the phenolic profile, α-amylase, α-glucosidase, ACE and Fe2+-induced lipid peroxidation in rat’ pancreas inhibitory effects of aqueous extracts from Plum and Hogweed leaves.: HPLC analyses revealed the presence of gallic, caffeic and p-coumaric acids, and cyanidin, catechin, quercetin, luteolin and kaempferol, with highest quantification found in Hogweed leaf except for gallic, and kaempferol which was only detected in Plum leaf. The IC50 values shown that the extract from Hogweed exhibited higher ?-amylase (IC50=17.95 μg/ mL), ?-glucosidase (IC50=13.69 μg/mL), ACE (IC50=14.16 μg/mL), and Fe2+-induced lipid peroxidation (IC50=81.58 μg/mL) inhibitory potentials when compared with that of Plum [?-amylase (IC50=25.89 μg/mL), ?-glucosidase (IC50=18.36 μg/mL), ACE (IC50=22.11 μg/ mL) and Fe2+-induced lipid peroxidation (IC50=107.54 μg/mL)]. These effects may be possible mechanisms by which these plants could be used in the prevention/management of TD2 and some allied complications such as hypertension. However, clinical and in vivo studies should be done to establish this claim.

Keywords: Medicinal plants; P. domestica; B. procumbens; Polyphenols; α-Amylase; α-Glucosidase; ACE; Antioxidant

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