Journal of Aging and Geriatric Medicine.ISSN: 2576-3946

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Review Article, J Aging Geriatr Med Vol: 4 Issue: 2

Cortical Dendritic Changes in Mouse Models of Frontotemporal Dementia

Ramy R Mitwalli*1,2

1Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, USA

2Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA

*Corresponding Author : Mitwalli RR
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, USA
Tel: +1 (202) 687-0100
E-mail:
[email protected]

Received: May 21, 2020 Accepted: May 25, 2020 Published: June 09, 2020

Citation: Mitwalli R (2020) Cortical Dendritic Changes in Mouse Models of Frontotemporal Dementia. J Aging Geriatr Med 4:2. doi: 10.37532/agm.2020.4(2).125

Abstract

Frontotemporal dementia (FTD) is a pre-senile dementia that is characterized by rapid, progressive neural deterioration and atrophy in the frontal lobe. As the disease progresses, the deterioration eventually advances to the temporal lobe as well. Nearly 20% of all pre-senile dementia cases are reported as frontotemporal dementia, making FTD second only to Alzheimer’s Disease (AD) in prevalence. However, as with AD, FTD still has no curative treatment. This has made FTD a target of much research as of late, and of particular interest are the histological pathologies and the associated changes in behavior and mental health of patients suffering from FTD.

Keywords: Frontotemporal Dementia; Alzheimer’ s disease; Mouse; Dendritic

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