Andrology & Gynecology: Current ResearchISSN: 2327-4360

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Research Article, Androl Gynecol Curr Res Vol: 4 Issue: 3

Endometrium Cancer: Evidence of Cooperative Effect of P53 Codon 72 and ACP1 Genetic Polymorphisms on Cancer Grade

Gloria-Bottini F1*, Nicotra M2, Spina C1, Benedetti-Panici PL2, Neri A1, Magrini A1 and Bottini E1
1Department of Biomedicine and Prevention, University of Tor Vergata, Roma, Italy
2Department of Gynaecologic, Obstetric and Urologic Sciences, University La Sapienza, Roma, Italy
Corresponding author : Fulvia Gloria-Bottini
Department of Biomedicine and Prevention, University of Tor Vergata Via: Montellie-100123 Roma, Italy
Tel: +39 06 30889514
E-mail:
[email protected]
Received: August 13, 2016 Accepted: September 15, 2016 Published: September 20, 2016
Citation: Gloria-Bottini F, Nicotra M, Spina C, Benedetti-Panici PL, Neri A, et al. (2016) Endometrium Cancer: Evidence of Cooperative Effect of P53 Codon 72 and ACP1 Genetic Polymorphisms on Cancer Grade. Androl Gynecol: Curr Res 4:2. doi: 10.4172/2327-4360.1000149

Abstract

Objective: In the present paper we have searched for a possible cooperative effect of p53 codon 72 and ACP1 genetic polymorphisms on cancer grade. Methods: 69 women with endometrium cancer and 696 adults without cancer have been studied. P53 codon 72 and ACP1 genotypes were determined by DNA analysis. Results: The analysis has shown a cooperative interaction between ACP1 and p53 codon 72 concerning the effect on cancer grade: the proportion of the joint genotype *Arg/*Arg carrying the low activity *A/*A and *A/*B ACP1 genotypes is lower in high grade than in low grade. The proportion of gametic type *A/*Arg is significantly lower in high than in low grade cancer. Conclusion: The combination of the effect of low activity ACP1 that may favor cellular growth with the increase of apoptosis due to *Arg allele could act against the progression towards forms with immature and undifferentiated cells protecting from severe manifestation of cancer.

Keywords: ACP1; p53; Genetic polymorphism; Endometrium cancer grade

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