Macrophage Migration Inhibitory Factor Gene Polymorphisms (MIF-173CC) Genotyping in Patients with Cardiac Dysfunction: Relationship to Diabetes Mellitus

Abdelsabour M^1*, Idriss NK², Mohamed NA², Osama AM² Gaber MA², Alfarash A³, Saad K⁴, Elgamal DA⁵

¹Department of Cardiology, Assiut University, Assiut, Egypt

²Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt

³Faculty of Agriculture, Assiut University, Assiut, Egypt

⁴Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt

⁵Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt

*Corresponding Author : Naglaa Kamal Idriss
Assoicate professor of Medical Biochemistry, Faculty of Medicine, Assiut University, Egypt
Tel: +201003830234
E-mail: naglaaidriss@hotmail.com

Received: May 01, 2018 Accepted: June 18, 2018 Published: June 26, 2018

Citation: Abdelsabour M, Idriss NK, Mohamed NA, Osama AM, Gaber MA, et al. (2018) Macrophage Migration Inhibitory Factor Gene Polymorphisms (MIF- 173CC) Genotyping in Patients with Cardiac Dysfunction: Relationship to Diabetes Mellitus. Int J Cardiovasc Res 7:4. doi: 10.4172/2324-8602.1000356

Introduction: Macrophage migration inhibitory factor (MIF) is an important mediator in inflammation and pathogenesis of cardiomyopathy (CMP). We aim to explore any possible association between polymorphisms of MIF genes and CMP in a cohort of Egyptian patients with cardiac dysfunction with or without diabetes mellitus and to investigate the alliance between the identified genotype and their medical features.

Patients and methods: This is a case-control study where 57 patients with CMP were consecutively admitted to CCU compared with 98 matched healthy controls. Patients were subjected to careful clinical history and physical examination, ECG, routine investigations, and echocardiography. All participants were analyzed for codon -173 G/C polymorphism in MIF genes by using PCR-RFLP methods.

Results: We found higher Frequency of MIF-173 GG genotype in both diabetic and nondiabetic CMP patients compared to controls (p<0.05). However, we did not find any significant difference in the MIF genotyping between the CMP with or without DM.

Conclusion: Our results advocate that MIF may have implications for our understanding of the pathophysiology and perturbation in CMP process. We suggested that GG genotype of MIF (-173) gene may be a risk factor for patients with CMP.