Short Communication, J Aging Geriatr Med Vol: 2 Issue: 2
Patients with Cognitive Impairment and Falls: Characteristics of a Group of Elderly Patients
Marta Neira Alvarez*
Department of Geriatric and Internal Medicine. University Hospital Infanta Sofía. S S Reyes, Universidad Europea Madrid, Madrid. Spain
*Corresponding Author : Marta Neira Alvarez PhD
Department of Geriatrics and Internal Medicine, University Hospital Infanta Sofía, S S Reyes, Madrid, Spain
Received: January 22, 2018 Accepted: February 22, 2018 Published: February 27, 2018
Citation: Alvarez NM (2018) Patients with Cognitive Impairment and Falls: Characteristics of a Group of Elderly Patients. J Aging Geriatr Med 2:2. doi: 10.4172/2576-3946.1000118
Cognitive impairment and falls are main geriatric problems, being falls 8 times more frequent in this group of patients. Our objective is to study differences in risk factors for falls in patients with cognitive impairment. Methods: A two year prospective study in a Fall Outpatient Clinic was carried out in patients.
Keywords: Cognitive impairment; Eldery patients; Dementia; Falls
Dementia is one of the most prevalent illnesses in elderly, with an estimation of 42 million people with the diagnosis worldwide. It is well known that dementia is a risk factor for falls, being falls 8 times more frequent in this group of patients, and it is likely that they have a multi-factorial etiology; possibly with risk factors similar to those identified in general population .
Falls are a main geriatric problem in elderly, not only because its prevalence but also because their consequences . They are the expression of a variety of elderly syndromes like gait disorders, polimedication, psychotropic drugs, sensory impairments, cardiovascular problems or cognitive impairment among others .
However, there may be other potentially modifiable factors in patients with cognitive impairment and these could be of interest to prevent falls in this group of patients.
The purpose of this study is to describe falls assessment in patients with cognitive impairment and to study differences to patients with no cognitive impairment who fall.
It is a prospective, observational study in patients aged 65 years and older evaluated in a Fall Outpatient Clinic of Infanta Sofia Hospital in Madrid between March 2014 and December 2016. All participants gave informed consent and the study protocol was approved by the Biomedical Investigation Committee of the Infanta Sofia University Hospital of San Sebastian de los Reyes (Madrid, Spain) in March 2014.
Inclusion criteria consisted in ≥65 year-old patients, who had fallen down in the last year with fall consequences that required medical assistance or those who had fallen two or more times in the past year. Patients with no mobility (classified 0 and 1 by Functional Ambulatory Classificator), severe dementia, severe sensory impairment or any other patients with terminal disease and life expectancy less than three months were excluded.
The fall assessment included medical history, medications, sensory impairment, functional, cognitive and social evaluation. Functional status was measured by Barthel Index  and Lawton y Brody Index  for basic and instrumental activities respectively. To evaluate cognitive status the clock test (TRO)  and Standardized Mini-Mental State Examination (MMSE)  were used. Nutritional screening was made by using Mini Nutritional Assessment (MNA) . Anthropometric measurements were: body mass index, calf and mid‐upper arm circumference. Fat Free Mass was assessed with bioelectrical impedance analysis with TANITTA BC-601 and the then calculated Fat Free Mass Index (FFMI) Kg/m2.
Muscle mass strength was assessed by hand grip strength using a standard adjustable handle dynamometer KERN & SOHN GmbH Balingen (Model; Elect WOC11007248). All measurements were performed with the dominant hand with a standard protocol. Hand grip strength measurements <21 Kg in women and <31 Kg in men were considered cut‐off point . Assessment of physical performance included Time up and Go Test (TUG) using the better of two trials and being cut‐off point 15 sec  and 4 meters walking speed, using the best of three trials and the standard cut-off of ≤0.8 m/s for slow gait speed .
Additional information was serum 25-hydroxyvitamin D levels that were measured by competitive enzyme immunoassay technique (ADVIA Centaur, Siemens Healthcare Diagnostics). Cognitive impairment was defined as patients with TRO <4 or MMSE <24 and a comparative analysis was made between these patients and those without cognitive impairment. Frailty was defined as a clinical syndrome in which three or more of the following criteria were present: unintentional weight loss (10 lbs in past year), self-reported exhaustion, weakness (grip strength), slow walking speed, and low physical activity (Fried criteria) .
ESPEN consensus statement was used to define malnutrition . There are two options for the diagnosis: The first one requires body mass index (BMI, kg/m) <18.5 to define malnutrition. The second option requires the combined finding of unintentional weight loss (mandatory) and at least one of either reduced BMI or a low fat free mass index (FFMI). Weight loss could be either >10% of habitual weight indefinite of time, or >5% over 3 months. Reduced BMI <22 kg/m and low FFMI is <15 and <17 kg/m in females and males, respectively.
Descriptive statistics were calculated for the main variables. Categorical variables were expressed as percentages and the quantitative variables as medians with interquartile range [IQR] or as a mean ± standard deviation (SD). Differences between individual groups were compared using Fisher’s Exact test for categorical data, Student’s t test for normally distributed data and Mann-Whitney U test for non-normally distributed data. A p<0.05 was considered statistically significant. All statistical analysis was performed using IBM SPSS 21.0(IBM Corp; Armonk, NY; USA).
One hundred patients with falls were evaluated during this period and sixty one had cognitive impairment with a MMSE < 24 or TRO < 4. (30 patients had a previous diagnosis of dementia and 31 as a new diagnosis after falls assessment). The characteristics of the patients are shown in Table 1. There was a high prevalence of comorbidities, visual impairment, polymedication and vitamin D deficit in both groups.
|Variables||Total||Cognitive Impairment||No cognitive Impairment|
|Age mean (SD)||84.4 (5.7)||85,0 (4,8)||83,4(6,0)|
|Women n (%)||71 (71.0)||46 (75,4)||16 (66,6)|
|Pathologies n (%):
|Visual impairment n (%)||34 (51.5)||18(47,4)||10(58,8)|
|Auditory impairment n (%)||19 (28.8)||11(28,9)||3(17,6)|
|Medications mean (SD)||8.3 (3.7)||8,7(3,3)||7,9(3,3)|
|Psychotropic medication mean (SD)||1.7 (1.4)||1,9(1,5)||1,5(1,2)|
|Home living n (%)||86 (86.0)||49,0(80,3)||22(91,6)|
|Vitamin D mean (SD)||24.8 (13.7)||24,6 (12,2)||26,2(17,7)|
|Vitamin D <30ng/ml n (%)||50 (50.0)||30(49,2)||14(58,3)|
Table 1: Characteristics of the study group.
When studying differences between patients with and without cognitive impairment we observed that diabetes was present in 31 (52.5%) patients with cognitive impairment and only in 6 (25.0%) patients without cognitive difficulties (p=0.022). Regarding nutritional assessment, 48 (80.0%) patients with cognitive impairment showed MNA screening below cut‐off point of 24 meaning that they were at risk of malnutrition and only 14 (58.3%) patients without cognitive impairment (p=0.041). We have also seen that they have more difficulties in basic and instrumental performance measured by Barthel Index and Lawton index. Table 2 summarizes main functional and nutritional differences between the two groups.
|Variables||Cognitive impairment||No cognitive impairment||p|
|Barthel Index, mean (SD)||82,2 (16,7)||93,1(6,8)||0,003|
|Lawton Index, mean (SD)||1,0(1,9)||3,2(2,8)||0,000|
|MNA screening , mean (SD)||20,0(4,8)||23,2(4,4)||0,007|
|MNA<24, n (%)||48(80)||14(58,3)||0,041|
|Body Mass Index, mean (SD)||27,1(3,7)||26,6(4,9)||0,6|
|Fat Free Mass Index, mean (SD)||16,6(2,0)||16,7(2,1)||0,7|
|Time up and go Test, mean (SD||19,6(8,0)||17,0(6,9)||0,1|
|Gait speed , mean (SD)||0,7(0,4)||0,7(0,2)||0,1|
|Grip strength <cut point*n (%)||55(93,2)||23 (95,8)||1,0|
Table 2: Nutritional assessment and functional performance.
Regarding main diagnosis, frailty syndrome was significantly more common in patients with cognitive difficulties (77.0%) than in the group with no cognitive difficulties (54.2%) (p=0.037). Table 3 shows diagnosis differences.
|Variables||Cognitive Impairment||No cognitive impairment||p|
|Malnutrition, n (%)||22(36,0)||11(45,8)||0,4|
|Frailty, n (%)||47(77,0)||13(54,2)||0,037|
|Prefrailty, n (%)||8(13,1)||5(20,8)||0,5|
Table 3: Diagnosis.
In this paper we describe prevalence of falls in patients with cognitive impairment and risk factors related to falls in these patients. In dementia patients annual incidence rate of falls ranges from 60% to 80%, which doubles the incidence for age-matched older adults without Dementia. The study describes a high prevalence of some factors classically associated to falls as polymedication, high use of psychotropics, sensory impairment, vitamin D deficit or depression or Parkinson disease. Previous studies have published similar results [14-16]. But this study identifies differences in the group of patients with cognitive impairment such as diabetes, functional impairment, nutritional risk and frailty syndrome. The precise mechanisms underlying the increased fall risk in cognitively impaired older adults are not completely understood. Previous studies of falls in patients with cognitive impairment focused in cognitive aspects or deficits that could explain this increased risk. It has been shown that memory impairment, reduced attentional resource or executive dysfunction are associated with gait dysfunction and variability in gait speed that leads to fall. One specific early change in gait seen among older adults with mild to moderate dementia is decrease in gait velocity [17,18].
It has been also described other risk factors that could be involved as psychotropic medication, neurocardiovascular instability, environment or extrinsic factors, and type of dementia (Parkinson dementia or Lewy body dementia have greater risk for falls or instability) . However, we have observed that frailty syndrome is more frequent in the group of patients with cognitive impairment. It is well known that frailty syndrome is related to falls [12,19] but it´s interesting that cognitive impairment patients who fall are more frail than non-cognitive impairment ones. Malnutrition is also related to falls and frailty. Neyens and Vellas both describe this relationship between falls and nutrition but we have found that nutrition is a differential risk factor in cognitive impairment fallers [20-22]. Diabetic patients have more risk of cognitive impairment but also they are in special risk of falls and related fractures [23,24]. So frailty, malnutrition risk and diabetes make cognitive impairment patients at special risk for falls.
There are limitations to our study. It is a small sample, patients were collected only from one single center and the analysis was mainly descriptive, but it provides a deep analysis of falls assessment and has allowed us to focus on these three aspects in future evaluations.
The results highlight the high prevalence of diabetes, frailty and malnutrition among fall patients with cognitive impairment and therefore the utility of functional and nutritional assessment in falls evaluation.
The author sincerely thank the rest of the Geriatric team (Estefania Arias, Rafael Bielza, Adoración Morales y Cristina Moreno) and Israel J. Thuissard and David Sanz-Rosa from Universidad Europea de Madrid for their support during the study.
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