International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovas Res Vol: 5 Issue: 6

Psychiatric Disorders In Takotsubo Cardiomyopathy Compared With Acute Coronary Syndrome Patients

Fabrizio Ugo1, Mario Iannaccone4, Fabrizio D’Ascenzo4, Ovidio De Filippo4, Dario Celentani4, Davide Lazzeroni2, Luca Moderato2, Francesco Saggese2, Silvia Mazzilli4, Nicola Gaibazzi3, Claudio Moretti4, Diego Ardissino3, Fiorenzo Gaita4 and Paolo Coruzzi2
1Division of Cardiology, San Giovanni Bosco Hospital, Torino, Italy
2Division of Cardiology, Preventive Cardiology and Rehabilitation, Don Gnocchi Foundation of Parma and Faculty of Medicine of University of Parma (Research Group “W. Osler”), Italy
3Department of Cardiology, University-Hospital of Parma, Italy
4Department of Cardiology, Citta’ della Scienza e della Salute, University of Turin, Italy
Corresponding author : Mario Iannaccone
Division of Cardiology, Città Della Salute e Della Scienza, Turin, Italy
Received: August 10, 2016 Accepted: September 14, 2016 Published: September 20, 2016
Citation: Ugo F, Iannaccone M, D’Ascenzo F, De Filippo O, Celentani D, et al. (2016) Psychiatric Disorders in Takotsubo Cardiomyopathy compared with Acute Coronary Syndrome patients. Int J Cardiovasc Res 5:6. doi: 10.4172/2324-8602.1000286


Introduction: Depression and anxiety represent a common pathway for patients presenting with Takotsubo Cardiomyopathy (TTC) and Acute Coronary Syndrome (ACS) although differences in prevalence and their potential relation to cardiac disease onset remain to be described. Method and Results: 41 consecutive female patients with diagnosis of TTC were prospectively enrolled and compared with 82 consecutive age/sex matched patients with ACS as control group in a 1:2 fashion. Prevalence of psychological disorder was significantly higher in TTC patients compared with ACS (49% vs 26% p=0.01). In the subgroup with psychological disease, patients with TTC were more often anxious, while patients with ACS were more often affected by depression (80% vs 38% and 15% vs 48% respectively, p=0.02). At multiple regres-sion analysis TTC was an independent predictor of psychiatric disorders (HR 1.28 CI 1.1-1.5, p<0.01). Conclusion: In a cohort of elderly women with TTC, the prevalence of psychological disease is higher and with oppo-site clinical features (anxious vs depressed) compared with a matched ACS cohort.

Keywords: Psychiatric disorders; Tako-tsubo cardiomyopathy; Depression; Anxiety

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