International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovas Res Vol: 6 Issue: 1

Right Ventricular Deformation in Asymptomatic Children with Type I Diabetes Mellitus

Mahmoud Soliman1*, Morad Beshay1, Rania El Zayat2 and Mohamed Abu el rous2
1Cardiology Department, Faculty of Medicine, Menoufia University, Egypt
2Pediatric Department, Faculty of Medicine, Menoufia University, Egypt
Corresponding Author : Mahmoud A Soliman, MD
Department of Cardiology, Faculty of Medicine, Menoufia University, Egypt
Tel: 01001600237
Received: September 12, 2016 Accepted: December 18, 2016 Published: January 10, 2017
Citation: Soliman M, Beshay M, El Zayat R, Abu el rous M (2017) Right Ventricular Deformation in Asymptomatic Children with Type I Diabetes Mellitus. Int J Cardiovasc Res 6:1. doi: 10.4172/2324-8602.1000297


Background: Right ventricular function in diabetic children was not fully addressed. Previous reports were mainly directed for the left ventricle. Our objective was to investigate the subclinical effects of diabetes on right ventricular systolic and diastolic function in asymptomatic children with type 1 D.M. using echocardiographic two dimensional strain and strain rate. Methods: This study was conducted on 45 children with type 1 DM and 20 apparently normal children with comparable age, sex and socioeconomic status as a control group. Each patient was subjected to history taking, physical examination, routine laboratory investigations and conventional echocardiographic examination. Apical four chamber view was used for offline analysis of RV deformation data including assessment of systolic strain (ε), peak systolic strain rate (SRs), peak early diastolic strain rate (SRe) and Peak late diastolic strain rate (SRa) obtained from the basal, mid and apical segments of the RV free wall. Results: Although conventional echocardiography failed to reveal any impairment in RV systolic performance (measured with Tricuspid Annular Plane Systolic Exercursion, TAPSE), the values of systolic strain and peak systolic strain rate in the basal, mid and apical segment of the RV free wall were significantly lower in DM group as compared with control group indicating impairment of RV systolic function. Similarly, decreased peak early diastolic strain rate in children with diabetes in RV free wall reflecting abnormalities of RV diastolic performance. Conclusion: Diabetes mellitus type 1 leads to RV systolic and diastolic dysfunction. Strain and strain rate imaging appear to be a sensitive tool for early detection such abnormalities.

Keywords: Right ventricular strain; Type 1 diabetes

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