Editorial, J Mol Cloning Genet Recomb Vol: 1 Issue: 1
The Arrival of ‘knockout’ Rats
Muhammad Farooq* and Gabrielle M. Hawksworth | |
University of Aberdeen, Scotland, UK | |
Corresponding author : Muhammad Farooq Molecular Toxicology Group, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK E-mail: m.farooq@abdn.ac.uk |
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Received: June 27, 2012 Accepted: June 27, 2012 Published: June 29, 2012 | |
Citation: Farooq M, Hawksworth GM (2012) The Arrival of ‘knockout’ Rats J Mol Cloning Genet Recomb 1:1. doi:10.4172/2325-9787.1000e101 |
Abstract
The Arrival of ‘knockout’ Rats
‘Knockout’ technology is a valuable tool in identifying causative genes resulting in disease states. Over the last three decades, it has only been possible to use the mouse for this purpose, owing to the non-responsiveness of rat embryonic stem cells (ESCs) to the culture conditions that were successfully used to construct ‘knockout’ mice. But during the last few years, this situation has changed and successful novel approaches for the construction of ‘knockout’ rats have brought the rat back centre stage.