Journal of Molecular Cloning & Genetic Recombination

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Editorial, J Mol Cloning Genet Recomb Vol: 1 Issue: 1

The Arrival of ‘knockout’ Rats

Muhammad Farooq* and Gabrielle M. Hawksworth
University of Aberdeen, Scotland, UK
Corresponding author : Muhammad Farooq
Molecular Toxicology Group, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
E-mail: [email protected]
Received: June 27, 2012 Accepted: June 27, 2012 Published: June 29, 2012
Citation: Farooq M, Hawksworth GM (2012) The Arrival of ‘knockout’ Rats J Mol Cloning Genet Recomb 1:1. doi:10.4172/2325-9787.1000e101

Abstract

The Arrival of ‘knockout’ Rats

‘Knockout’ technology is a valuable tool in identifying causative genes resulting in disease states. Over the last three decades, it has only been possible to use the mouse for this purpose, owing to the non-responsiveness of rat embryonic stem cells (ESCs) to the culture conditions that were successfully used to construct ‘knockout’ mice. But during the last few years, this situation has changed and successful novel approaches for the construction of ‘knockout’ rats have brought the rat back centre stage.

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