International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovas Res Vol: 5 Issue: 5

The Association between Arterial Stiffness and Post-cardiac Surgery Renal and Diastolic Heart Functions

Jae-Sung Choi1*, Se Jin Oh1, Hack-Lyoung Kim2, Yong Won Sung1, Hyeon Jong Moon1, Jeong Sang Lee1 and Sohee Oh3
1Department of Thoracic and Cardiovascular Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea
2Department of Cardiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea
3Department of Biostatistics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea
Corresponding author : Jae-Sung Choi, MD, PhD
Department of Thoracic and Cardiovascular Surgery, SMG-SNU Boramae Medical Center, 20 Boramae-Ro 5-Gil, Dongjak-Gu, Seoul 156-707, Korea
Tel: 82-2-870-2293
Fax: 82-2-870-3866
E-mail: [email protected]
Received: June 22, 2016 Accepted: July 11, 2016 Published: September 01,2016
Citation: Choi JS, Oh SJ, Kim H,Sung YW, Moon HJ (2016) The Association between Arterial Stiffness and Post-cardiac Surgery Renal and Diastolic Heart Functions. Int J Cardiovasc Res 5:5. doi:10.4172/2324-8602.1000279

Abstract

Background: Brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness (AS), is a well-known non-invasive marker of cardiovascular morbidity but its implication for the cardiac surgery patients has been rarely studied. This study investigated the association between baPWV and post-cardiac surgery renal and left ventricular (LV) diastolic functions. Methods: Among 62 patients prospectively enrolled at a single center, 60 (mean age: 66.8 ± 9.1 years, 53.3% males) completed the whole measurements including baPWV and postoperative morbidity variables. Results: In total, 38 patients (63.3%) underwent non-valvular operations (NV), of which 32 underwent isolated coronary artery bypass grafting. Postoperative estimated glomerular filtration rate (eGFR) was significantly and inversely associated with baPWV, in both univariable and multivariable analyses (P=0.024, regression coefficient (B)=-1.535 and P=0.031, B=-1.190, respectively). In ROC curve analysis of patients undergoing NV for detection of postoperative eGFR <50 mL/min/1.73m2, the cut-off value of baPWV was 18.0m/s with 64.3% sensitivity and 75.0% specificity (AUC, 0.783; 95% CI: 0.631–0.934, P=0.004). For the association with postoperative LV diastolic function which was investigated with tissue Doppler echocardiography in a subgroup of patients undergoing NV, there was a significant trend of decreasing postoperative e′ velocity with increasing quartiles of baPWV: Q1, 6.8 ± 1.2; Q2, 6.3 ± 2.2; Q3, 5.0 ± 1.0; Q4, 5.2 ± 1.5 cm/s (P for trend=0.005). Conclusions: There was a significant inverse association between baPWV and post-cardiac surgery renal and LV diastolic functions. Trial registration: ClinicalTrials.gov (ID: NCT 02014012).

Keywords: Pulse wave velocity; Acute kidney injury; Diastolic dysfunction

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