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International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 3 Issue: 2

Pharmacological and Non- Pharmacological Therapies of Catecholaminergic Polymorphic Ventricular Tachycardia

Marai I1*, Boulos M1, and Khoury A2
1The division of Pacing and Electrophysiology, Rambam Health Care Campus and Bruce Rappaport, Israel Institute of Technology, Haifa, Israel
2The Department of Pediatric Cardiology, Rambam Health Care Campus and Bruce Rappaport Faculty, Israel Institute of Technology, Haifa, Israel
Corresponding author : Ibrahim Marai
The division of Pacing and Electrophysiology, Department Of Cardiology, Rambam Medical Center, 31096 Haifa, Israel
Tel: 972-4-8542180; Fax: 972-4-8542354
E-mail: [email protected]
Received: March 12, 2014 Accepted: April 09, 2014 Published: April 11, 2014
Citation: Marai I, Boulos M, Khoury A (2014) Pharmacological and Non-Pharmacological Therapies of Catecholaminergic Polymorphic Ventricular Tachycardia. Int J Cardiovasc Res 3:2. doi:10.4172/2324-8602.1000162

Abstract

Pharmacological and Non- Pharmacological Therapies of Catecholaminergic Polymorphic Ventricular Tachycardia

Polymorphic Ventricular Tachycardia (CPVT) is an inherited cardiac channelopathy characterized by exercise related ventricular tachycardia (VT) manifested as syncope and sudden death among young patients with structurally normal hearts. High dose Beta blocker is the mainstay therapy. Recently, flecainide was introduced to treat symptomatic CPVT patients despite beta blockers. Implantable cardioverter defibrillator is recommended for symptomatic patients if optimal medical treatment does not control ventricular arrhythmias. Left cardiac sympathetic denervation should be considered for intractable cases.

Keywords: Catecholaminergic polymorphic ventricular tachycardia; Calsequestrin; Ryanodine; Flecainide; Left cardiac sympathetic denervation

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