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International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 1 Issue: 3

Platelet Dysfunction and Coronary Artery Disease after Pediatric Kidney Transplantation

Iqbal CW1, Kamath AS2, Dean PG2, McBane RD3 and Ishitani MB2*
1Children’s Mercy Hospitals and Clinics, Kansas City, MO, USA
2Division of Transplant Surgery, Mayo Clinic Rochester, USA
3Division of Vascular Medicine, Mayo Clinic Rochester, USA
Corresponding author : Michael B. Ishitani, MD
200 1st Street SW, Rochester, MN 55905, USA
E-mail: [email protected]
Received: August 01, 2012 Accepted: August 24, 2012 Published: August 30, 2012
Citation: Iqbal CW, Kamath AS, Dean PG, McBane RD, Ishitani MB (2012) Platelet Dysfunction and Coronary Artery Disease after Pediatric Kidney Transplantation. Int J Cardiovasc Res 1:3. doi:10.4172/2324-8602.1000103

Abstract

Platelet Dysfunction and Coronary Artery Disease after Pediatric Kidney Transplantation

Children and adolescents undergoing kidney transplantation have an inordinately higher rate of early onset coronary artery disease (CAD) compared to age- and gender-matched controls. As allograft and patient survival rates have improved pediatric kidney transplant recipients are living longer and developing associated cardiac risk factors. As a result, CAD is the most common cause of death in this patient population. We hypothesized that platelet dysfunction would correlate with the severity of CAD found by EBCT in young adults who underwent a kidney transplant as a child or adolescent.

Keywords: Pediatric transplant; Kidney transplant; Atherosclerosis; Platelet dysfunction

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