Journal of Primary & Acquired Immunodeficiency ResearchISSN: 2324-853X

Editorial, J Immunodefic Disor Vol: 1 Issue: 2

A Potential Role for Host-Microbe Dysbiosis in Enteropathy Associated with HIV Infection, Immune Complex Diseases

Michael D. George*
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, USA
Corresponding author : Michael D. George
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, USA
Tel: 530-754-7242; Fax: 530-754-7240
E-mail: [email protected]
Received: August 01, 2012 Accepted: August 02, 2012 Published: August 05, 2012  doi:10.4172/2324-853X.1000e107
Citation: Getachew A. Dagne (2012) Methods for Analyzing Immunodeficiency Data with a Lower Limit of Quantification . J Immunodefic Disor 1:1. doi:10.4172/2324-853X.1000e105

Abstract

A Potential Role for Host-Microbe Dysbiosis in Enteropathy Associated with HIV Infection

Human immunodeficiency virus (HIV) infection progressively depletes CD4+ T-lymphocytes from the immune system and, in the absence of treatment, leads to acquired immune deficiency syndrome (AIDS). Gut associated lymphoid tissue (GALT) harbors a majority of the body’s lymphocytes and is an early and important mucosal target of HIV infection. The massive and rapid depletion of CD4+ T cells from GALT in primary HIV infection is presumed to be an underlying cause of a progressive deterioration of intestinal immune and digestive functions collectively termed “enteropathy”. The most common clinical manifestations of HIV-associated enteropathy, diarrhea and malnutrition, have a devastating impact on the day-today lives of millions of patients world-wide.

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