International Journal of Cardiovascular ResearchISSN: 2324-8602

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Research Article, Int J Cardiovasc Res Vol: 4 Issue: 2

Pre-existing Medical Conditions among Pregnant Women with Cardiomyopathy

Chad A Grotegut1*, Cary C Ward2, Margaret G Jamison3 and Andra H James1
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA
2Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA
3Centers for Disease Control and Prevention, National Center for Health Statistics, Research Triangle Park, North Carolina, USA
Corresponding author : Chad A. Grotegut, MD MHS
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, DUMC Box 3967, Durham, NC 27710, North Carolina, USA
Tel: + 919-681-5220; Fax: 919-681-7861
Received: June 16, 2014 Accepted: September 26, 2014 Published: September 29, 2014
Citation: Grotegut CA, Ward CC, Jamison MG, James AH (2015) Pre-existing Medical Conditions among Pregnant Women with Cardiomyopathy. Int J Cardiovasc Res 4:2. doi:10.4172/2324-8602.1000201


 Pre-existing Medical Conditions among Pregnant Women with Cardiomyopathy

Background: The purpose of this study was to identify medical conditions and obstetric complications associated with all forms of cardiomyopathy in pregnancy. Study Design: The Nationwide Inpatient Sample (NIS) for the years 2000-2007 was queried for all pregnancy-related discharges. The ICD-9 codes for cardiomyopathy were used to identify cases and were compared to women without cardiomyopathy. Results: During the 8-year period 2000-2007, there were 36,930 records with a diagnosis of cardiomyopathy in pregnancy for a rate of 0.98 per 1000 pregnancy-related discharges. At an admission for delivery, multivariable logistic regression demonstrated that chronic hypertension and preexisting heart disease were the pre-existing conditions that best predicted cardiomyopathy (OR 2.9, 95% CI 2.6, 3.3 for hypertension, OR 71.3, 95% CI 62.2, and 81.8 for pre-existing heart disease). Cardiac and pulmonary events that occurred during a delivery hospitalization were the two types of acute events most associated with cardiomyopathy in pregnancy (OR 34.7, 95% CI 28.8, 41.9 for cardiac event and OR 29.4, 95% CI 25.1, 34.4 for pulmonary events). Conclusions: Women with pre-existing cardiac disease and hypertension are at significantly increased risk for developing cardiomyopathy in pregnancy. Hypertension is a potentially modifiable risk factor that may ultimately decrease the risk for cardiomyopathy in pregnancy.

Keywords: Cardiomyopathy; Hypertension; Mortality; Nationwide inpatient sample; Pregnancy

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