International Journal of Cardiovascular ResearchISSN: 2324-8602

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Case Report, Int J Cardiovasc Res Vol: 4 Issue: 5

Prevention of Venous Thromboembolism in Major Orthopedic Surgery: Bayesian Network Meta-Analysis of 21 Randomized Trials Evaluating Unfractionated Heparins, LowMolecular Weight Heparins, and New Oral Anticoagulants

Andrea Messori1*, Sabrina Trippoli1, DarioMaratea1, Valeria Fadda1 and Claudio Marinai2
1HTA Unit, ESTAR, Regional Health Service, Firenze, Italy
2Department of Pharmaceutical Logistics, ESTAR, Regional Health Service,Firenze, Italy
Corresponding author : Andrea Messori
HTA Unit, ESTAR, Regional Health System, Via San Salvi 12, 50100, Firenze, Italy
Fax: +390574701319
E-mail: [email protected]
Received: March 17, 2015 Accepted: May 19, 2015 Published: May 21, 2015
Citation: Messori A, Trippoli S, Maratea D, Fadda V, Marinai C (2015) Prevention of Venous Thromboembolism in Major Orthopedic Surgery: Bayesian Network Meta-Analysis of 21 Randomized Trials Evaluating Unfractionated Heparins, Low-Molecular Weight Heparins, and New Oral Anticoagulants. Int J Cardiovasc Res 4:5. doi:10.4172/2324-8602.1000225

Abstract

Prevention of Venous Thromboembolism in Major Orthopedic Surgery: Bayesian Network Meta-Analysis of 21 Randomized Trials Evaluating Unfractionated Heparins, LowMolecular Weight Heparins, and New Oral Anticoagulants

Objective: In major orthopedic surgery, the prevention of venous thromboembolism has been based, over the past decades, on unfractionated heparins (UFHs), then on low-molecular weight heparins (LMWHs) and, more recently, on new oral anticoagulants (NOACs). To summarize the comparative effectiveness of UFHs, LMWHs, and NOACs in this clinical indication, we applied Bayesian network meta-analysis to the clinical material (randomized studies) published in two previous reviews focused on this issue. Our endpoint was a composite of venous thromboembolism and pulmonary embolism.

Methods: Our analysis was based on standard Bayesian network meta-analysis (random-effect model).

Keywords: Venous thromboembolism; Low molecular weight; Heparins; Unfractionated heparins; Novel oral anticoagulants; Meta analysis; Clinical pharmacy

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