A new methodology in drug delivery
Mehran Ghiaci
Isfahan University of Technology, Iran
: J Pharm Drug Deliv Res
Abstract
Our main goal in presenting this methodology was to modify the conventional systemic delivery of drugs because such procedures may cause toxicity; for example, polymeric coatings may present some disadvantages such as limited chemical stability, local inflammatory reactions and so on. As a result, we thought that it could be interesting to embed bioactive compounds and biomolecules within inorganic coating such as TiO2, ZrO2, and SiO2. This type of coating increases drug passage time through its small and long pores forward intended fluid (whether in vitro or in vivo) and eliminates different stimuli such as (temperature, pH, ultrasonic irradiation,...) to remove the coating on the surface of drug carrier system. This could be very effective economically and time spent. Moreover, if such inorganic coatings have nanostructure properties, they improve cellular adhesion, enhances osteoblast proliferation, and increase biomineralization. In this talk, emphasis is placed on presenting the technique, and would like to explore it as a new methodology in drug delivery.
Biography
