Anticandidal activity of extracts and novel compound isolated from Petriella setifera

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Amani S Awaad

Prince Sattam bin Abdulaziz University, Saudi Arabia

: J Pharm Drug Deliv Res

Abstract

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A novel triterpenoidal compound commonly named amnomopin (3β-diglucoside-5, 12-28-oic acid) was isolated from the Petriella setifera. The total alcoholic extract of P. setifera showed a great activity against clinically isolated Candida species including Candida albicans, C. dubliniensis, C. famata, C. glabrata, C. inconspicua, C. kefyr, C. krusei, C. norvegensis, C. parapsilosis, C. tropicalis. Also, the new compound amnomopin was active against all the investigated Candida species. The highest anticandidal activity of Petriella stifera extract was obtained against C. kefyr (22.6±1.5 mm), C. albicans and C. norvegensis (21.3±0.63 mm), and C. krusei (20.6±1.5 mm). Moreover, the MICs of both the total extract and the isolated compound were low. The minimum inhibitory concentration of the compound isolated from Petriella stifera was 00.49 µg/ml against C. kefyr, 00.98 µg/ml against C. albicans and C. norvegensis, and 01.95 µg/ml against C. krusei. The oral dosage of the extract and the isolated compound did not show any significant effect on the activity of aspartate transaminase (ALT), alanine transaminase (AST) and the levels of blood urea and serum creatinine. amaniawaad@hotmail.com a.awaad@psau.edu.sa

Biography

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