Anti-carcinogenic effect of co-administration of α-β unsaturated compounds and quercetin
Gabriela Carrasco Torres
Centro de Investigación y de Estudios Avanzados del IPN, Mexico
: J Pharm Drug Deliv Res
Abstract
The effect of co-administration of α-β unsaturated compounds derivatives of benzoic acid and the flavonoid quercetin were evaluated in a variety of established human cancer cell lines. The synergic effect of these two chemicals showed anti-proliferative activity in cancer liver cells of 90% and in cancer cervical cells of 60% at 48 hour post-treatment. Additionally significant events of apoptosis were observed in 90% of the cell population, when benzoic acid and quercetin were administered together. Independent treatments, quercetin or α-β unsaturated compounds decrease the migratory ability of HepG2, HuH7 and HeLa, however the coadministration of both, exerted a higher effect. It is suggested by in silico studies of α- β unsaturated compounds, that through 1, 4-addition reactions Michael type, they can selectively react with glutathione (GSH). High levels of GSH participate as a defence mechanism characteristic of cancer cells, thereby, inhibiting free radical induced cell death. Summarizing the co-administration of these compounds induce programmed cell death, probably by disrupting the cellular redox homeostasis, so further studies of the effect of independent or co-administration of these compounds, will give us the best way to use them as chemotherapeutic agents.
Biography
Email: carrasco@cell.cinvestav.mx
