Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604

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Controllable continuous sub-tenon drug delivery of dexamethasone disodium phosphate to ocular posterior segment in rabbit


Xuetao Huang, Yezhen Yang, Yiqin Duan, Manqiang Peng, Kuanshu Li  and Ding Lin

Changsha Aier hospital, China

Central South University, China

: J Pharm Drug Deliv Res

Abstract


Aim: To explore the feasibility of Sub-tenon’s Controllable Continuous Drug Delivery to ocular posterior segment. Materials & Methods: Controllable continuous sub-tenon drug delivery(CCSDD),intravenous injections(IV) and sub-conjunctival injections (SC) were used to deliver Dexamethasone Disodium Phosphate (DEXP) in rabbits , the dexamethasone concentration were measured in the ocular posterior segment tissue by high-performance liquid chromatography-mass spectrometry method (HPLCMS) at different time points in 24 hours after first dose injection. Results: Levels of dexamethasone were significant higher at 12, 24 hour in CCSDD than two other approach, and at 3h, 6h in CCSDD than IV in vitreous body(P<0.01); at 6h, 12h, 24h in CCSDD than two other approach, and at 1h, 3h in CCSDD than IV in retinal/ choroidal compound (P<0.01); at 3h, 6h, 12h, 24h in CCSDD than two other approach, and at 1h in CCSDD than IV in scler (P<0.05). The AUC0-24 in CCSDD group is higher than two other groups in all ocular posterior segment tissue. Conclusion: Our results demonstrated that dexamethasone concentration could be sustained moderate higher in the posterior segment by CCSDD than SC and IV, indicated it might be a therapeutic alternative to treat a variety of intractable posterior segment diseases.

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