Development and characterization of self-micro-emulsified drug delivery systems for Cisplatin
Irfan Akartas and Karasulu H Y
Ege University, Turkey
: J Pharm Drug Deliv Res
Cancer, today, is one of the most threatening diseases to society. Ovarian cancer is the 9th most common cancer in women and the most lethal gynecologic cancer. Cisplatin is indicated in primary, advanced stage and refractory ovarian cancer. Classical drug application routes in chemotherapy are oral and intravenous. There are some disadvantages of these methods. Absorption of the drugs used for the oral route is not complete. The aim of this study is to develop a new self microemulsion drug delivery system (SMEDDS) for cisplatin to enhance the oral bioavailability of drug. In this study, isopropyl myristate was used as the oil phase, Kolliphor were used as the surfactant, and propylene glycol was used as the co-surfactant. SMEDD formulations were characterized (table 1) and dissolution studies were evaluated in pH 6.8 phosphate buffer (figure 1). Permeation studies were examined with Caco-2 cell culture.