Development and evaluation of Self-Emulsifying Drug Delivery System (SEDDS) pellet for Atorvastatin calcium
M Diril, H Y Karasulu and I Nikolakakis
Ege University, Turkey
Aristotle University of Thessaloniki, Greece
: J Pharm Drug Deliv Res
Atorvastatin calcium is poorly soluble in water and anti-hyperlipidemic drug, having a biological half-life of 14 hours. Lipidbased formulations have attracted attention in recent years because it improves the solubility of active substances showing low solubility and low bioavailability in gastrointestinal tract. These formulations have many advantages such as easy to prepare, can reduce the impact of food and reduce interpersonal variation. Self-emulsifying pharmaceutical pellets combine the advantages of emulsions and solid dosage forms, improved absorption of low solubility drugs and better stability in the gastric fluids. Among the approaches to improve the oral bioavailability, the use of self-emulsified drug delivery pellet systems (SEDDS-pellet) has been shown to be reasonably successful in improving the oral bioavailability of poorly water-soluble and lipophilic drugs. The aim of this study is to develop a new dosage form, alternative to the classical tablet forms of Atorvastatin. In this study, oleic acid was used as the oil phase, Tween 20 and Span 80 were used as the surfactants, N-methylpyrrolidone was used as the co-surfactant and both avicel and aerosol were used as the solid phase. The prepared SEDDS-pellet formulations are characterized for size, shape, density and stability and dissolution studies. Permeation studies were examined with caco-2 cell culture. According to results, SEDDS-pellet formulation had a higher permeability value than the conventional tablet formulation.