Develpoment and characterization of clarithromycin loaded porous scaffold film as wound dressing material
Jashanjit Singh
Swift School of Pharmacy, India
: J Pharm Drug Deliv
Abstract
In the present study, porous scaffold films of Clarithromycin were prepared by the process of solvent casting method. The porous films were prepared using chitosin dissolved in acetic acid in different concentrations and PEG-4000 which works as plasticizer and porosity enhancer. The preliminary drug identification studies showed that drug confers to all standard values for solubility, melting point, UV and IR. Porous films prepared by solvent casting method with different polymer concentrations were subjected to various investigations namely moisture content, water absorption ratio, swelling index, porosity, folding endurance, tensile strength, entrapment efficiency and in-vitro drug release. Formulation FB4 was found to be an optimized formulation with moisture content 4.36±0.316, water absorption ratio 245±1.57, swelling index 219.47±3.66, porosity 54.71±0.737, folding endurance 213±4.16, tensile strength 43.7 mJ/cm2 and in-vitro drug release 99.64±0.88 for 12 hrs. From the present study we concluded that porous scaffold film of Clarithromycin was successfully prepared by solvent casting method using chitosin polymer in different ratio with PEG-4000 to achieve a controlled and efficient release of the drug. Overall the porous scaffold films offered potential advantage of high drug loading capacity (up to 99%) and homogenous drug dispersion.
Biography
Email: jas_nirman@rediffmail.com
