Dissolution enhancement of Aceclofenac tablet by solid dispersion technique

Kiroj Rajbanshi

Dissolution enhancement of Aceclofenac tablet by solid dispersion technique

Kiroj Rajbanshi

Kathmandu University, Nepal

: J Pharm Drug Deliv Res

Abstract

The study was carried out to enhance the dissolution rate of poorly water soluble drug Aceclofenac (BCS-II), by solid dispersion technique using different carrier and super disintegrant by Kneading method. Design of Experiment performed for screening of carrier and super disintegrant that has better effect on dissolution was Placket Burman Design. Carriers that were chosen for the study include hydroxypropyl beta cyclodextrin, premix of lactose and maize starch and mannitol. Similarly for superdisintegrant sodium starch glycolate, croscarmellose and crospovidone were selected. Among the carriers and superdisintegrants, mannitol and crospovidone showed best effect on dissolution. For optimizaton of concentration of mannitol and crospovidone in solid dispersion, central composite design was applied for two factors at two levels which gave 13 formulations. Tablets were prepared and evaluated for physiochemical properties. Response surface plot and contour plot were drawn and an optimum formulation was selected. This formulation contained 114.14 mg of mannitol and 10.5 mg crospovidone. The in vitro dissolution studies of optimized formulation CCDF8 and marketed product was carried out in USP Type II apparatus at different time interval of 5, 15, 30 and 45 minute at 50 rpm in phosphate buffer, pH 7.5 (0.33M mixed). Solid state characterization was evaluated by FTIR. It showed that the drug was stable in solid dispersion. Hence, Solid dispersion technique can be sucessfully used for the improvement of the dissolution profile of Aceclofenac.