Enhancing the solubility of a drug using novel formulations
Abdullahi A S, Muhammad Surajo and Usman Jamilu
Sokoto State University, Nigeria
: J Pharm Drug Deliv Res
Abstract
Use of inorganic mesoporous silica substances in formulation to improve the dissolution of poorly water soluble drugs is a fast developing area in pharmaceutical drug research. In this research, three different mesoporous silica (silica gel, syloid AL 1 FP and syloid XDP 3050) micro particles were utilized in enhancing the solubility of phenylbutazone. They were formulated by means of wet mixtures using water as a solvent at different drug/excipient mass ratios of 50:50 (w/w), 60:40 (w/w), 70:30 (w/w) for silica gel and syloid AL 1 FP, while syloid XDP 3050 was formulated at 50:50 (w/w), 40:60 (w/w) and 30:70 (w/w) drug/excipient mass ratios. All the particles before and after formulation were investigated for their morphology and size distribution via microscopy and malvern mastersizer. In vitro dissolution analysis was carried out in order to investigate their pharmaceutical performance. This analysis demonstrated that the release of phenylbutazone in the samples prepared with syloid XDP 3050 was 85.13±2.55% in 15 minutes and 99.62±2.95% in 30 minutes. Upon all formulations investigated, this release was the best and the greatest achieved during this study in comparison to only 24.57±1.40% and 43.66±2.25% release of the pure phenylbutazone over the same period. Drug formulation with silica gel exhibited the slowest release in comparison to the formulations with two syloid silicas, this deviation is thought to be as a result of a larger particle size of the silica gel and also during the formulation, drug crystals and silica gel particles did not mix well together due to the large mass of drug used.
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