ERCC1 expression in metastatic triple negative breast cancer patients treated with platinum-based chemotherapy
EL Baiomy MA, Wagdi F Elkashef
Mansoura University, Egypt
: J Clin Exp Oncol
Background: Possible targeted therapies for metastatic triple negative breast cancer (TNBC) include cytotoxic chemotherapy that causes interstrand breaks (platinumbased drugs). The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway, removes platinum-induced DNA adducts and cisplatin resistance. Objective: To assess the impact of ERCC1 expression on PFS, OS and response rate in metastatic triple negative breast cancer patients treated with platinum-based chemotherapy.
Materials and methods: From June 2012 to November 2013, 52 metastatic triple negative breast cancer patients were enrolled. ERCC1 protein expression was detected from pretreatment biopsies by Immunohistochemistry. All patients received cisplatin plus paclitaxel. The primary end point was the impact of ERCC1 expression on PFS and OS. Results: 34 patients (65.4%) showed positive ERCC1 expression while 18 patients (34.6%) showed negative ERCC1 expression. Positive ERCC1 expression was associated with short PFS (median, 5 months vs. 7 months; P = 0.043). Positive ERCC1 expression was associated with short OS (median, 9 months vs. 11 months; P = 0.033). Also, positive ERCC1 expression was associated with poor response to cisplatin based chemotherapy (P = 0.046).
Conclusions: This prospective study further validates ERCC1 as a reliable biomarker for customized chemotherapy in metastatic triple negative breast cancer patients and shows that high expression of ERCC1 was significantly associated with poor outcome in patients treated with platinum based chemotherapy.
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