Formulation and evaluation of gastro retentive microspheres containing rizatriptan benzoate
Bhambere Deepak Sunil, Ahirrao Sapana Prabhakar, Thombre Nilima Abhijit, Raut Tushar Sahebrao and Bhambere Tushar Sunil
MET’s Institute of Pharmacy, India
: J Pharm Drug Deliv Res
Abstract
Migraine is a common, chronic, incapacitating neurovascular disorder, characterized by attacks of severe headache, autonomic nervous system dysfunction, and in some patients, an aura involving neurologic symptoms. Migraine is characterized by episodes of head pain that is often throbbing and frequently unilateral and may be severe. Studies on anti-migraine drugs showed that vasoconstriction from 5-HT, ergotamine and nor-adrenaline could reduce migraine attacks. Triptans are specific and selective agonists for the 5-HT1 receptors. Rizatriptan is a triptan that is rapidly absorbed and highly bioavailable with proven efficacy for treating migraine with rapid onset of effect after oral administration. Drugs that are easily absorbed from the stomach and have a short half-life are eliminated quickly from the blood circulation, require frequent dosing. To avoid this problem, the oral gastroretentive formulations have been developed in an attempt to release the drug slowly into the gastric region. By considering above need an attempt was made to prepare mucoadhesive microspheres containing Rizatriptan benzoate using 23 full factorial designs.
Biography
