Formulation of iron-coated liposomes of SERM and design development of magnetic belt for the management of breast cancer during earlier stages and protection from invasive cancer
Prashant S Khemariya
SRK Pharmaceutical, India
: J Pharm Drug Deliv Res
Abstract
Breast cancer remains the utmost common invasive cancer and the second leading cause of cancer mortality for women in the United States. Worldwide, breast cancer comprises 22.9% of all cancers (excluding non-melanoma skin cancers) in the women. It is estimated that, globally, over 508,000 women died in 2011 due to breast cancer (Global Health Estimates, WHO 2013). Liposomes are attractive due to their unique opportunities together with negligible side effects not only in cancer but also in the treatment of other diseases. In this study, our aim is to develop combined prospective of iron-coated liposomes (of raloxifene hydrochloride) and design a magnetic belt (magnetism < 0.1 T) for the management of breast cancer during earlier stages and prevention from developing invasive cancer, and osteoporosis in post-menopausal women. Keeping this objective, the present systematic study was focused to design magnetic belt in shape of women’s breast that will contain few magnetic fires having enough magnetism to attract iron-coated liposomes only during oral administration of raloxifene hydrochloride, in order to overcome the poor bioavailability issue with the drug as well. Raloxifene or methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy] phenyl] hydrochloride (a Selective Estrogen Receptor Modulator-SERM) is FDA approved drug and is used to decrease the chance of invasive breast cancer in post-menopausal women who have a high risk for developing the disease or who have osteoporosis. After oral administration of iron-coated liposomes, they will distribute throughout the body through the systemic circulation while the magnetic belt will be on the cancer site (breast). This belt results in accumulation of liposomes which will concentrate at the site of cancer because of the iron and magnet interaction. Ultimately, drug concentration and absorption will also enhance on the surrounding areas of cancerous cells where the cancerous cells will be denatured quickly
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