Nanoelectronic detection of dynamic cell functions
Peng Chen
Nanyang Technological University, Singapore
: J Electr Eng Electron Technol
Abstract
As the current follows solely or largely on the surface, the conductance of the semiconducting nanomaterials is highly sensitive to the electrochemical perturbation induced by the interacting biomolecules or by biological activities of the interacting cells. Taking advantage of this, nanoelectronic biosensors based on these nanostructured materials have been developed, promising novel applications for fundamental studies, diagnosis, and drug screening. This presentation briefly reviews our works on the nanoelectronics-biology interface. More specifically, we have developed and used nanoelectronic fieldeffect transistors based on carbon nanotubes, graphene, or silicon nanowires to electrically detect the presence of biomolecules or dynamic activities of live cells (secretion of biomolecules or chemicals, ion channel activities, metabolic activities), with high sensitivity, high temporal resolution, and high throughput.
Biography
