Nanoemulsion containing Sargassum extract as anti-aging cosmeceutical

Marianti Manggau, Yayu Mulsiyani, Elly Wahyudin, Nurfadillah Bakri, Siswanto Wahab, Ermina Pakki and Elmi Zainuddin

Nanoemulsion containing Sargassum extract as anti-aging cosmeceutical

Marianti Manggau, Yayu Mulsiyani, Elly Wahyudin, Nurfadillah Bakri, Siswanto Wahab, Ermina Pakki and Elmi Zainuddin

Hasanuddin University, Indonesia

: J Pharm Drug Deliv Res

Abstract

Aging process can be prevented by using effective cosmeceutical with antioxidant and sun protecting activity. Recently, we found that ethanol extract of brown algae Sargassum spp., has anti-oxidant and sun protecting activity. Nanoemulsion loaded with Sargassum spp., was investigated its physical properties after storage for three months. Antioxidant activity was measured by using DPPH assay, sun protecting activity was also shown by measurement of sun protection factor (SPF). The in vitro skin permeation study was also done. Skin irritation test, clinical evaluation for skin moisturizing effect and skin elasticity were performed in 30 healthy persons. The results showed that the nanoemulsion was physically stable, and also exhibited antioxidant activity and sun protecting activity. From the in vitro permeation test, flavonoid compound was mostly remained in stratum corneum, viable epidermis and dermis rather than in blood circulation which was related to cosmetic purpose. From clinical studies we showed that the skin hydration and elasticity were significantly increased after using the nanoemulsion containing Sargassum extract. Our results strongly indicated that nanoemulsion containing Sargassum extract was a promising anti-aging cosmeceutical.