Neural activity is pivotal for myelin growth
Alessandro Morelli
Genova University, Italy
: J Spine Neurosurg
Abstract
A new paradigm other than insulator may arise for myelin, consistent to the fact that myelination is not continuous, as previously thought, and that myelin can aerobically synthesize ATP and deliver it to the axoplasm trough gap-junctions. Myelination is triggered by neuronal activity, which in turn regulates myelin remodeling. It may be hypothesized that after birth, intense firing depletes axonal ATP causing a rise in Adenosine, that triggers myelination (through purinergic receptor signalling): only those neurons which are fed with ATP can survive. Anoxia causes memory loss: i.e. memory requires energy. It may represent a neural network energized by myelination
Biography
Alessandro Morelli (b. 1943) has studied enzyme Glucose-6-P-dehydrogenase and its molecular mechanism of senescence. He has been working in the field of phototransducion and molecular events in photoreceptor cells of vertebrate retina. He has discovered the protein FX, a NADP dependent enzyme catalizing synthesis of GDP-L-fucose. He has been working on the effects of electromagnetic fields of extremely low frequency on the activity of enzymes involved in bioenergeticprocess. Recently he has studied the myelin energetic function in brain put in in evidence the ATP extramitochondrial synthesis, with application in the study of Multiple Sclerosis and other neurodegenerative deseases
