Optimized formulation, preformulary characterization and evaluation of Diethylcarbamazine citrate - Medicated chewing gum

Swati Khare

Optimized formulation, preformulary characterization and evaluation of Diethylcarbamazine citrate - Medicated chewing gum

Swati Khare

College of Pharmacy IPS Academy, India

: J Pharm Drug Deliv Res

Abstract

Truncate infections caused by Helminthes, or parasitic worms, affect more than two billion people worldwide. Looking at this situation, an attempt has been made to formulate a novel drug delivery system known as medicated chewing gum containing masticatory gum base with pharmacologically active ingredient Diethylcarbamazine citrate (used as a first-line agent for control and treatment of Lymphatic filariasis and for therapy of tropical pulmonary eosinophilia caused by Wuchereria bancrofti and Brugia malayi). Optimized formulations of medicated chewing gum with varying concentration of gum base were formulated. Evaluation parameter like Texture analysis (Hardness, Firmness and Springiness test) is carried out by Texture analyzer apparatus (TAXT plus). Improved essentials of casting & in-vitro release profile of drug in saliva was obtained by formulation Fc3 (96.2%). Buccal absorption studies showed that 39.2% of drug absorbed within one minute when available to buccal mucosa at pH 5.5, commensurate with explain diethylcarbamazine citrate- medicated chewing gum (DEC-MCG) can be considered as better formulation for buccal drug delivery system in which drug is absorbed buccally and reaches the systemic circulation via jugular vein.