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Organogel nanoparticles as delivery system for lipophil

Journal of Pharmaceutics & Drug Delivery Research .ISSN: 2325-9604

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Organogel nanoparticles as delivery system for lipophilic drugs


Sophie Franceschi

Paul Sabatier University, France
: J Pharm Drug Deliv Res

Abstract


In recent years, a growing interest has emerged in the development of semi-solid colloidal careers for the delivery of water-insoluble drugs. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Careers (NLC) are example of such systems. As an alternative to SLN, we propose the use of an original family of organogel nanoparticles. Organogels are semi-solid materials in which an organic solvent (e.g., vegetable oil) is entrapped in the three-dimensional fibrous network formed by self-aggregation of a low molecular mass organic gelator (12-hydroxystearic acid). The preparation process of the gelled oil nanoparticles is based on the sol-gel phase transition of the organogel obtained by hot emulsification (T°>T°gel) in presence of an aqueous solution of stabilizing agent (polyvinyl alcohol 80), leading to a stable semi-solid dispersion after cooling (T°

Biography


Sophie Franceschi has her expertise in “Chemical and physicochemical studies of organized molecular systems for drug delivery and material applications”. She has 20 years of experience in Research and Teaching. She completed her Graduation and PhD at Paul Sabatier University of Toulouse (France) in 1997 and completed her Master’s Degree in Molecular and Supramolecular Chemistry. Currently, she is a Researcher in SMODD group in the IMRCP laboratory at Paul Sabatier University of Toulouse and also a teacher at Paul Sabatier University.

Email: sfrances@chimie.ups-tlse.fr

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