Organogel nanoparticles as delivery system for lipophilic drugs
Sophie Franceschi
Paul Sabatier University, France
: J Pharm Drug Deliv Res
Abstract
In recent years, a growing interest has emerged in the development of semi-solid colloidal careers for the delivery of water-insoluble
drugs. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Careers (NLC) are example of such systems. As an alternative to
SLN, we propose the use of an original family of organogel nanoparticles. Organogels are semi-solid materials in which an organic
solvent (e.g., vegetable oil) is entrapped in the three-dimensional fibrous network formed by self-aggregation of a low molecular
mass organic gelator (12-hydroxystearic acid). The preparation process of the gelled oil nanoparticles is based on the sol-gel phase
transition of the organogel obtained by hot emulsification (T°>T°gel) in presence of an aqueous solution of stabilizing agent (polyvinyl
alcohol 80), leading to a stable semi-solid dispersion after cooling (T° Sophie Franceschi has her expertise in “Chemical and physicochemical studies of organized molecular systems for drug delivery and material applications”. She has 20 years of experience in Research and Teaching. She completed her Graduation and PhD at Paul Sabatier University of Toulouse (France) in 1997 and completed her Master’s Degree in Molecular and Supramolecular Chemistry. Currently, she is a Researcher in SMODD group in the IMRCP laboratory at Paul Sabatier University of Toulouse and also a teacher at Paul Sabatier University. Email: sfrances@chimie.ups-tlse.frBiography
