Parenteral emulsions: Emulsion dosage forms; challenges and opportunities
Mehdi Gholami Davoudi
Caspian Tamin Pharmaceutical Company, Iran
: J Pharm Drug Deliv Res
Abstract
Parenteral emulsions are one of the most appropriate dosage forms for insoluble medicines administration. Some of the physicochemical properties such as Hydrophilic Lipophilic Balance (HLB), Zeta potential, and particle size distribution, which should be considered to achieve a reliable formulation, might make this a real challenge for formulators. Moreover the intended manufacturing methods and quality control depended on expensive process and laboratory equipments, high pressure homogenizer, Dynamic light scattering (DLS) and expensive excipients such as injectable grade egg lecithin and soy bean oil. Nevertheless, as reviewing literatures shows that current commercial preparations may cause some adverse reactions like such as pain at the site of injection, and anaphylactic hypersensitivity reactions in patients who are sensitive to egg derivates or some unwanted properties like stability problems, microbial growth susceptibility. Indicated issues encourage scientists to develop new patents, modify current manufacturing processing work on new formulation methods for commercial purpose i.e. Phase Inversion Temperature (PIT) method for emulsification, spontaneous method for emulsification, lipid & egg lecithin free emulsion and LCT-MCT emulsions. On the other hand this complicated process and required investment makes this market more protected from generic manufacturing. Market has a great potential for new emulsion development in oncology products, poorly soluble APIs as well as targeted therapies.
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