Pharmaceutical evaluation of nano-fiber matrix supported drug delivery system using solventbased electrospinning method
Nobuhito Shibata
Doshisha Women’s College of Liberal Arts, Japan
: J Pharm Drug Deliv Res
Abstract
The solvent-based Electrospinning (ES) method is mainly employed in the textile industry to make nano-fiber from polymers. Utilizing this method, nano-fiber matrix supported controlled-release systems of drugs were prepared and evaluated, where, methacrylic acid copolymer (EUDRAGIT® S100, MCA) was used as a base polymer. Using the ES apparatus equipped with a highvoltage supplier, syringe pump and a metallic collection plate for nano-fiber, the polymer solution including drug (hydrophilic or hydrophobic) was extracted into a glass syringe with a stainless steel needle (18 gauge), and the syringe was fixed at a designated position in the ES apparatus. The voltage applied between the needle and the metallic collection plate was 25 kV with a collection distance of 10 cm. The polymer solution including the drug was then pushed out at a constant flow rate. Consequently, a nano-fiber was formed from the stream of polymer solution in the electric field, and a self-assembled nano-fiber sheet was obtained on the metallic collection plate. The X-ray diffraction for the nano-fiber sheet showed that drugs were packed into nano-fiber in amorphous form. Then, the nano-fiber sheet including drug was applied for several drug delivery systems as a nano-fiber matrix. In vitro release profiles and in vivo pharmacokinetic profiles of drugs from the formulation including nano-fiber matrix in rats and/or mice showed the aspects of controlled-release system as compared to conventional preparations. Moreover, the nano-fiber matrix is applicable for both hydrophilic and hydrophobic drugs, and provides new approaches to prepare several formulations with pharmaceutical advantages.
Biography
Nobuhito Shibata finished his Master’s degree course of clinical pharmacy at Kyoto Pharmaceutical University in 1986. He, then, worked for Shiga University of Medical Science for 13 years as a Hospital Pharmacist. During this period, he got a PhD degree (Pharmaceutical Sciences) from Kyoto Pharmaceutical University. Subsequently, he changed his career and worked for Kyoto Pharmaceutical University for 6 years as an Associate Professor in the field of pharmacokinetics. In 2005, he was transferred to a higher post at Doshisha Women’s College of Liberal Arts as a Professor of Faculty of Pharmaceutical Science. His research interests focus on the constructing drug delivery system using nano-particles.
E-mail: nshibata@dwc.doshisha
